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Cardinals vs. Padres odds, line: 2021 MLB picks, Sunday Night Baseball predictions for May 16 from top model

The St. Louis Cardinals will look to avoid the sweep when they take on the San Diego Padres on Sunday Night Baseball. The Cardinals (23-17), who are 5-5 in their last 10 games, hold a three-game lead over Milwaukee in the NL Central Division. The Padres (23-17), who are 6-4 in their last 10 games, have won 10 of their last 13 meetings against St. Louis. San Diego has won eight of the past 12 contests against the Cardinals at Petco Park.

First pitch from Petco Park in San Diego is set for 7:08 p.m. ET. The Cardinals are 17th in MLB with a .233 team batting average, while the Padres are 18th at .231. San Diego is a -125 favorite on the money line in the latest Cardinals vs. Padres odds from William Hill Sportsbook, while the over-under for total runs scored is 7. Before making any Padres vs. Cardinals picks, check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league’s last full schedule, returning more than $1,400 on its top-rated money-line and run-line MLB picks. It is off to a fast start in 2021, going 44-31 on top-rated MLB money-line picks through six weeks, returning over $700. Anyone following it has seen huge rewards. 

Now, the model has dialed in on Cardinals vs. Padres on Sunday Night Baseball. You can visit SportsLine now to see the picks. Here are the MLB lines and trends for Padres vs. Cardinals:

  • Cardinals vs. Padres money line: St. Louis +115, San Diego -125
  • Cardinals vs. Padres run line: San Diego -1.5
  • Cardinals vs. Padres over-under: 7 runs
  • STL: The Cardinals are 4-1 in their last five games against a left-handed starter
  • SD: The Padres are 11-2 in their last 13 Sunday games

Featured Game | San Diego Padres vs. St. Louis Cardinals

Why you should back the Padres

San Diego shortstop Jake Cronenworth has been on a tear. He has a three-game hitting streak and has hits in 14 of his past 17 games, including six multi-hit games during that stretch. On Saturday, he was 3-for-4 with a walk in the Padres’ 13-3 win. Since April 24, Cronenworth has raised his batting average 33 points to .289 with three homers and 11 RBIs. In two career games against St. Louis, he is 4-for-8 (.500) with two walks.

Third baseman Manny Machado has also been on a roll with hits in seven of nine games. He is 3-for-7 (.429) in the series with a double and four RBIs. For the season, Machado is hitting .236 with five homers and 26 RBIs. He has had St. Louis’ number through the years. In 21 career games against the Cardinals, he is hitting .333 with four doubles, nine homers and 28 RBIs.

Why you should back the Cardinals

Left-hander Kwang Hyun Kim (1-0, 2.74 ERA) makes the start for St. Louis. It will be his first regular-season appearance on the West Coast in his MLB tenure. Kim has been sharp and has not allowed more than one run in each of his last four starts. On Tuesday at Milwaukee, he pitched 5 1/3 innings, allowing five hits, one earned run and one walk, while striking out six. For the season, he has walked five while striking out 24.

St. Louis, which is without shortstop Paul DeJong (broken rib), has been led on offense by third baseman Nolan Arenado, who is 7-for-13 (.538) over the past three games. He has hits in 11 of his past 12 games and has raised his average 31 points over that span. He is 4-for-8 (.500) in the series with a double and two home runs. In 130 career games against the Padres, Arenado is hitting .293 with 22 doubles, five triples, 27 home runs and 77 RBIs.

How to make Padres vs. Cardinals picks

SportsLine’s model is leaning over on the total, as the teams combine for 7.4 runs in the simulations, and it also says one side of the money line has all the value. You can only see the pick at SportsLine

So who wins Cardinals vs. Padres? And which side of the money line has all the value? Visit SportsLine now to see which side of the money line to jump on, all from the advanced model off to a hot start in 2021.

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